The typical characteristic of w-shape work roll wear was found in roll serving period. In order to restrain and uniform roll wear distribution, decrease wear peak and improve and eliminate the surface defects of work roll，the wear prediction model of work roll was developed for the 2250mm hot strip temper mill，and the shifting style, shifting step and shifting rhythm which were the main effective factors were studied and the optimized work roll shifting strategy was developed．Through trial on the 2250 hot temper mill，it is shown that the work roll wear peak is less than 40 μm and decreased by 20 %；the shape adjustment characteristic is improved and the bending force adjustment scope is decreased by 30%；the roll consumption is reduced，the roll serving time is prolonged and the unit roll consumption is decreased by 20 %．