Abstract: The effects of the oxide layer and various annealing processes on the microstructure and mechanical pro-perties of Ni22Cr3 alloy were investigated using optical microscopy,scanning electron microscopy,energy-dispersive spectroscopy（EDS）,X-ray diffraction（XRD）,universal tensile testing machine,and hardness tester. The results showed that the main component of the outer oxide layer of Ni22Cr3 alloy is Fe₃O₄,and the inner oxide layer is Fe₂O₃ and Cr_1.3Fe_0.7O₃.With the increasing of annealing temperature and holding time,the grain grows gradually and the carbide dissolves gradually. When the solution temperature is 900 ℃,the carbide dissolves slowly,the grain grows slowly and the size is heterogeneous. When the annealing temperature increases to 950 ℃,the grains grow rapidly and the size is homogeneous. When the annealing temperature increases from 800 ℃ to 1 000 ℃,the yield strength decreases from 300 MPa to 200 MPa,the tensile strength decreases from 660 MPa to 580 MPa,the elongation increases from 40% to 48% and then decreases to 43.5%,the hardness decreases from 150 HV to 123 HV. According to the experimental analysis,the optimal annealing process for achieving the ideal microstructure and properties of the Ni22Cr3 alloy cold-rolled coil products is holding at 950 ℃ for 4 min. Based on the effective length of the annealing furnace of 90 m,the calculated product line speed is 22.5 m/min. The microstructure and properties of the products manufactured by this process fully meet the operating requirements.