Abstract: With the continuous increase in the city's development requirements for architectural aesthetics, asymmetric skewed special-shaped steel arch bridges have been gradually applied to key landmark buildings such as urban transportation hubs and landscape bridges in recent years due to their unique structural mechanical form and aesthetic visual impact. In order to clarify the seismic performance of asymmetric skewed special-shaped steel arch bridges and optimize the structural design parameters, this paper, relying on the Hefei Nanfei River Key Project-Guangde Road Bridge, establishes a seismic finite element analysis model of the asymmetric skewed bridge based on the results of the bridge's dynamic response test and verifies its accuracy. The dynamic time-history analysis of the asymmetric skewed special-shaped steel arch bridge under modified Taft seismic wave is carried out, and the effects of key parameters such as the rise-to-span ratio, the elevation difference of the arch ribs, the inward inclination angle of the arch ribs, the location of the arch crown, and the complex arch springing configurations on the seismic performance of the bridge are clarified. The results show that the seismic response of the two sides of the asymmetric skewed special-shaped arch bridge shows obvious differences. The peak vertical displacement occurs at the mid-span of the middle arch rib（D_x=24.06 mm）, the peak axial force of the structure occurs at the top of the side diagonal braces in the form of tension（F_N= 2 701 kN）, and the peak vertical bending moment occurs at the foot of the side arches of the north bank（M_y=9 062 kN·m）. At the same time, the structural design of Guangde Road Bridge still has some optimization space, and its relative optimized structural design parameters are a rise-to-span ratio of 1/3.45 to 1/3.10, an arch rib elevation difference of 8.6%, an arch rib inclination angle of 10°00′, and an arch crown position of 0.55L, while retaining the design configuration of the tie rods and diagonal braces in the complex arch springing region. The research results may provide a reference basis for the seismic performance evaluation and structural design optimization of similar asymmetric special-shaped steel arch bridges.