Abstract: This study investigated the effects of calcination conditions and acid-leaching parameters on the reactivity of Guangxi white clay and Shanxi coal-series kaolin. The alumina dissolution rate was determined using EDTA complexometric titration and XRF spectroscopy,respectively,to identify the optimal calcination regime for each material. Under the optimized calcination conditions,the calcined kaolin samples were subjected to acid-leaching tests with varying parameters to evaluate alumina dissolution. Response surface methodology was applied to optimize the acid-leaching conditions,and corresponding validation experiments were conducted. The results indicate that Guangxi white clay achieved the highest activity after calcination at 850 ℃ for 4 h,while Shanxi coal-series kaolin exhibited maximum activity when calcined at 800 ℃ for 3 h. Variations in acid-leaching parameters—including leaching temperature,time,solid-to-liquid ratio,and hydrochloric acid concentration—all influenced the alumina dissolution rate to some extent. The predicted optimal acid-leaching conditions derived from the response surface regression model showed minor deviations from the actual experimental results,demonstrating that the model can be effectively applied to optimize the acid-leaching conditions for metakaolin.