Abstract: The steelmaking-continuous casting process acts as the core segment of iron and steel production. Basic Oxygen Furnace (BOF) tapping delay serves as a typical production disturbance, which severely hinders the dynamic-orderly and synergetic-collaborative continuous operation of material flow across multiple working procedures. This paper takes a steelmaking plant in China as the research object, adopts Plant Simulation software to establish a multi-process simulation model for steelmaking-continuous casting production, and explores the impact of BOF tapping delay disturbance on actual production performance. This paper analyzes the adverse effects of tapping delay under diverse production operation modes through simulation experiments, and formulates targeted operation adjustment rules and corresponding mathematical models for steelmaking-continuous casting production to address tapping delay disturbances. The experimental results show that under the constraints that LF/RH soft blowing can be shortened by a maximum of 7 min and the continuous casting cycle can be extended by a maximum of 5 min, solutions have been obtained for different degrees of tapping delays under three typical working conditions: delays only affecting the subsequent processes of the disturbed heat (15 min and 18 min delays), delays affecting subsequent heats of the same converter without casting sequence adjustment (5 min, 10 min and 16 min delays), and delays affecting subsequent heats of the same converter requiring casting sequence adjustment (33 min delay), which ensure continuous casting of the caster. This paper systematically dissects the influence mechanism of BOF tapping delay disturbance under multiple production modes. The formulated operation adjustment rules can provide practical guidance for on-site production optimization and disturbance governance, and further guarantee the dynamic-orderly and synergetic-collaborative continuous operation of the steelmaking-continuous casting section.