Abstract: Aiming at the problem of fatigue failure of rolls caused by alternating contact stress of Sendzimir mill, the contact stress distribution and fatigue failure mechanism of rolls were explored. Based on the influence function method, the contact pressure calculation model between rolls was established. The crack initiation life model was established by using the local stress and strain method of damage mechanics. The crack propagation life model was established by using the crack growth rate method of fracture mechanics. The real-time production data was integrated to develop the roll fatigue life prediction model system. According to the internal fatigue distribution of the roll, the grinding amount can be reasonably formulated, the over-limit fatigue layer can be removed, the safety of the roll can be guaranteed, and the rolling kilometers can be effectively increased. It is of great significance to realize precise grinding roll, precise preparation roll and precise use roll.