Abstract: In recent years, Titanium/steel clad plates have been widely utilized in the petrochemical industry due to their outstanding comprehensive properties. However, the relatively narrow roll-bonding process window constrains stable, high-quality production. Therefore, TA10/14Cr1MoR clad plates were prepared by vacuum rolling cladding technology. The effects of heating temperature on the microstructure, element diffusion behavior and interface bonding properties of TA10/14Cr1MoR clad plates were studied by means of electron probe microanalyzer(EPMA), scanning electron microscope(SEM), electron back scattering diffraction(EBSD) and shear test. The results show that the thickness of decarbonized layer, interfacial reactive layer and β-Ti layer increased with the rising of heating temperature, and the product and distribution of the interfacial reactive layer determine the interfacial bonding properties. At 850 ℃ and 900 ℃ of heating temperatures, the diffusion of Fe in α-Ti was relatively limited, resulting TiC layer at the interface, and the average shear strength was 254 MPa and 328 MPa, respectively. The fracture mainly occurred in TA10 substrate, and the discrepancy in shear strength was primarily related to the microstructure of TA10 substrate at different temperatures. At 950 ℃ of heating temperature, the concentration of the C element at the interface was reduced, and the diffusion reaction between Fe and Ti element intensifies. This results in the formation of an uneven TiC+FeTi intermetallic compounds layer at the interface, which caused brittle fracture mainly along the interface, with low shear strength and large fluctuation. Compared with commercial pure titanium, the heating temperature of TA10/steel clad plate can be increased to 900 ℃ due to its higher β phase transition temperature, and the process window for regulating the microstructure properties of steel substrate was expanded.