Abstract: Aiming at the challenge of simultaneously enhancing the strength and corrosion resistance of 2195 Al-Li alloy through traditional aging treatment, this study aims to explore the regulatory effects of the coupled process of pre-deformation and non-isothermal aging on its microstructure, mechanical properties and corrosion behavior so as to seek an efficient heat treatment scheme with excellent comprehensive performance. Solution-treated 2195 Al-Li alloy samples were subjected to pre-deformations of 4%, 8% and 10% followed by non-isothermal aging treatment heating at a rate of 20 ℃/h to 200 ℃ and then cooling at a rate of 40 ℃/h to 100 ℃. Tensile tests, scanning electron microscopy (SEM) and optical microscopy were used to systematically analyze the mechanical properties, fracture morphology, precipitate characteristics and intergranular corrosion behavior of the alloy under different processing conditions. The results show that pre-deformation significantly promotes the fine and dense precipitation of T₁ phase (Al₂CuLi). All alloys reach the peak strength when cooled to 160 ℃. The 10% pre-deformed sample has the highest yield strength 535 MPa while the 8% pre-deformed sample has the best comprehensive performance with the maximum strength-ductility product. Microstructural analysis shows that the 8% pre-deformed sample has the narrowest precipitate-free zone PFZ at grain boundaries and its fracture surface presents a large number of dimples and tear ridges showing transgranular ductile fracture. Non-isothermal aging treatment also significantly improves corrosion resistance. The intergranular corrosion depth of the 8% pre-deformed sample is only 36.7 μm which is about 60% lower than that of the traditional peak-aged state 91.8 μm.This result is attributed to its fine T₁ phase and narrow PFZ. The coupled treatment of pre-deformation and non-isothermal aging can synergistically optimize the strength, ductility and corrosion resistance of 2195 Al-Li alloy. Among the tested conditions 8% is the optimal pre-deformation amount. This process not only greatly shortens the aging time of peak strength from 16 h to 6 h with an efficiency improvement of 62.5% but also achieves excellent comprehensive performance matching by refining intragranular precipitates and narrowing grain boundary PFZ providing an important basis for the development of heat treatment processes for aerospace components.